cell interactions – Communicable Diseases Research

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Article

Published on 2022-08-232022-11-16
Journal: ACS Nano
[Category] COVID19(2023년), SARS, 치료기술,

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology
[Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells epithelial cells. expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells

SARS-CoV-2에 대한 고친화성 중화 항체는 T 여포 보조 세포 없이 만들 수 있습니다.

Article

Published on 2022-02-042022-09-11
Journal: Science Immunology
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] (Beta absence Alternative pathway antibody antibody production Antiviral B cell B cell response B cell responses B.1.351 Cell cell interaction cell interactions cells complement damaged driver effective epitope epitope mapping Epitopes Evidence evidence of follicular Germinal center high affinity homologous Immunoglobulin immunoglobulin class immunoglobulin class switching Infection Inflammation Influenza influenza A influenza A virus influenza A virus infection Neutralizing neutralizing antibody occur operative pathway Patient patients Protective reactive receptor reduced responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing severe COVID-19 Support switching T cell These data variant Viral viral infection virus infection
[DOI] 10.1126/sciimmunol.abl5652 PMC 바로가기 [Article Type] Article

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.

Research Article

Published on 2022-01-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used
[DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article

Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19

말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.

Article

Published on 2021-10-012022-09-11
Journal: Science China. Life sciences
[Category] SARS, 유전자 메커니즘,

[키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell RNA-seq. single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19
[DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

인간 세포에서 SARS-CoV-2 감염을 조절하는 microRNA의 역할: 체계적인 검토

Article

Published on 2021-07-012022-09-11
Journal: Infection, genetics and evolution : journal of mol
[Category] SARS, 변종,

[키워드] ACE2 addition Analysis applied article association caused cell interactions cleavage Complex network Complex networks COVID-19 COVID-19 patients Critical database disease eligibility criteria Evidence expression level expression levels function Gene Expression gene target Genes Genome Genome sequencing highlight host cells host genes host miRNA host miRNAs host responses human disease human infection in silico independent infected cell Infection infections Interaction microRNA MicroRNAs miRNA miRNAs modulating MOST Mutation Pathologies predicted Prospective PROSPERO Proteins protocol provide Registered regulate reported Research review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates searched selected Sequencing specimen suggested systematic review therapeutic target therapeutic targets TMPRSS2 translation viral genome virus virus infection
[DOI] 10.1016/j.meegid.2021.104832 PMC 바로가기 [Article Type] Article

Mechanisms of radiation-induced endothelium damage: Emerging models and technologies

Review article

Published on 2021-05-012022-10-05
Journal: Radiotherapy and oncology : journal of the Europea
[Category] 비임상,

[키워드] Activation acute radiation syndrome Adherens junctions AJAdherens junctions alteration apoptotic pathways ARSAcute radiation syndrome Ataxia telangiectasia-mutated ATMAtaxia telangiectasia-mutated biomimetic microfluidic assay bMFAbiomimetic microfluidic assay cardiovascular disease cell interactions cellular and molecular Central nervous system CNSCentral Nervous System Critical CVDCardiovascular disease Damage-associated molecular patterns DAMPDamage-associated molecular patterns develop Developing dysfunction ECEndothelial cell endothelial Endothelial cell Endothelium exposure G-CSFgranulocyte-colony stimulating factor Gastrointestinal Geranylgeranylacetone GGAGeranylgeranylacetone GIGastrointestinal GM-CSFGranulocyte/Macrophage Colony Stimulating Factor granulocyte-colony stimulating factor Granulocyte/Macrophage Colony Stimulating Factor Human umbilical vein endothelial cells HUVECHuman umbilical vein endothelial cells ICAM-1Intercellular adhesion molecule 1 IL-1interleukin-1 in vitro model in vivo Inflammatory response Injury Intercellular adhesion molecule 1 interleukin-1 ionizing radiation IRionizing radiation JAK1Janus kinase 1 JAM-CJunctional adhesion molecule-C Janus kinase 1 Junctional adhesion molecule-C knowledge LETLinear energy transfer leukocyte Linear energy transfer M-CSFmacrophage colony-stimulating factor macrophage colony-stimulating factor major histocompatibility complex management Manganese-dependent superoxide dismutase mechanism Medical countermeasures MHCMajor Histocompatibility Complex Microphysiological systems MnSODManganese-dependent superoxide dismutase morbidity and mortality MPSMicrophysiological systems NETsNeutrophil Extracellular Traps Neutrophil extracellular traps nuclear organ damage organs oxygen radical PAFPlatelet activating factor PAI-1plasminogen activator inhibitor type 1 pathology PDGFplatelet-derived growth factor PKCδProtein Kinase C-delta plasminogen activator inhibitor type 1 platelet activating factor platelet-derived growth factor Prevent protease PROTECT Protein Kinase C-delta Radiation radiological Radiotherapy reactive oxygen species resulting ROSreactive oxygen species SRSStereotactic radiosurgery stereotactic radiosurgery TBItotal body irradiation TEERTransendothelial electrical resistance TGFβTransforming Growth Factor-Beta therapeutic thought thrombomodulin tight junctions tissue tissue damage tissue injury TJTight junctions TMthrombomodulin TNF-αtumor necrosis factor-α total body irradiation Transendothelial electrical resistance Transforming Growth Factor-Beta Treatment tumor necrosis factor-α TYK2Tyrosine Kinase 2 Tyrosine Kinase 2 Vascular damage WBCWhite blood cells Weapons of mass destruction White blood cells WMDWeapons of mass destruction
[DOI] 10.1016/j.radonc.2021.02.007 [Article Type] Review article

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

Research

Published on 2020-12-242022-10-05
Journal: Nature biotechnology
[Category] SARS, 유전자 메커니즘, 치료법,

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens
[Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article

Cell Biology of Viral Infections

Editorial

Published on 2020-11-072022-10-31
Journal: Cells
[Category] Coronavirus, SARS,